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June 8, 2021    Dave

In western countries, 6-10% of the adult population is affected by insomnia. Difficulty maintaining sleep, difficulty initiating sleep, frequent awakenings, and sleep deprivation are some of the most common complaints of insomnia. Age-related changes in sleep, depression, medication use, chronic anxiety, and alcoholism are some of the factors contributing to insomnia. (1)

If you wish for a better night's sleep without any disrupted sleep latency, then this article is for you. This article will explain how insomnia can be managed and treated with Eszopiclone and why it is better than other medications.

What is Eszopiclone?

Eszopiclone is a new generation hypnotic drug and a stereoisomer of Zopiclone. This sedative-hypnotic produces a calming effect by working on special chemicals present in your brain. Eszopiclone comes under different brand names and as a generic drug, helping you fall asleep and stay asleep. (2)

As effective as benzodiazepines, Eszopiclone has been approved by the FDA for treating insomnia by reducing sleep onset latency. Eszopiclone can also be used in combination with different treatment methods like relaxation techniques and behavior modification. (3)

How Does Eszopiclone Help?

Your brain has some of the very important neurotransmitters called γ- Aminobutyric acid (GABA). GABA receptors are inhibitory receptor, and Eszopiclone works on these receptors to treat insomnia. The mechanism of how Eszopiclone works on these receptors is still not completely understood. But many studies report that Eszopiclone interacts with the complexes of GABA receptors having binding domains located close to benzodiazepine receptors.

Your body tissues, including the brain, quickly absorb the Eszopiclone drug. The liver metabolizes Eszopiclone, which is then converted into its metabolite called N-oxide. The N-oxide metabolite is responsible for inducing and maintaining the sleep effect. (4)

How is Eszopiclone Better than Zopiclone?

Compared to Zopiclone, Eszopiclone comes with a better safety profile and rapid improvement in chronic insomnia. Let's talk about some research studies reporting the efficacy of Eszopiclone vs Zopiclone.

According to a study, patients were suggested to take 3mg of Eszopiclone and 7.5mg of Zopiclone for one month. The results showed the efficacy of Eszopiclone over Zopiclone for improving sleep efficiency and increasing total sleep time. Both medications showed similar safety profiles. (5)

In another research study, the therapeutic effects of Eszopiclone were investigated. It was reported that you could use Eszopiclone for more than four weeks because Eszopiclone is not limited to short-term use. Moreover, it was suggested that a 3mg dose of Eszopiclone was enough for improved sleep maintenance. (6)

How to use Eszopiclone?

  • The recommended dose of Eszopiclone is 3 mg which should be taken by mouth before bedtime.
  • Your doctor prescribes the dose of Eszopiclone based on your condition, liver function, other medications you might be using, and your age.
  • If you eat a heavy meal or high-fat meal, it is essential not to take medicine right after the meal.
  • If you have started taking medicine, it is suggested that you should not work the next day because you feel less focused, alert, and concentrated.
  • If you’re an older adult with more than 60 years of age and have a liver or kidney disease, your doctor will prescribe the low dosage.
  • Speak with your doctor before stopping the usage of medication. If you suddenly stop taking the medication, you may experience withdrawal effects, such as shakiness, vomiting, stomach cramps, nausea, and nervousness. (7,8)

Things to Consider While Taking Eszopiclone:

Clinical Monitoring

When you start taking Eszopiclone, several health issues must be monitored by you and your doctor. This is important because, in this way, you will be sure that you're safe during the treatment. Clinical monitoring includes:

  • Problems with liver function
  • Dizziness
  • Excessive drowsiness
  • Reduced mental functioning


  • The drug should be kept away from heat and sunlight.
  • Eszopiclone should not be stored in a damp or moist place, such as a bathroom.
  • Controlled room temperature(15°C and 30°C) is suitable for storing Eszopiclone. (9)

A Word From Us:

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  1. Rösner S, Englbrecht C, Wehrle R, Hajak G, Soyka M. Eszopiclone for insomnia. Cochrane Database Syst Rev [Internet]. 2018 [cited 2021 Jun 2];(10). Available from: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010703.pub2/full?cookiesEnabled
  2. Dautovich ND, Williams JM, McCrae CS. Insomnia: A Review of the Use of Eszopiclone. Clin Med Ther. 2009 Jan 1;1:CMT.S1940.
  3. Najib J. Eszopiclone, a nonbenzodiazepine sedative-hypnotic agent for the treatment of transient and chronic insomnia. Clin Ther. 2006 Apr;28(4):491–516.
  4. Monti JM, Pandi-Perumal S. Eszopiclone: its use in the treatment of insomnia. Neuropsychiatr Dis Treat. 2007 Aug;3(4):441–53.
  5. Pinto LR, Bittencourt LRA, Treptow EC, Braga LR, Tufik S. Eszopiclone versus Zopiclone in the treatment of insomnia. Clinics. 2016 Jan;71(1):5–9.
  6. Brielmaier BD. Eszopiclone (Lunesta): a new nonbenzodiazepine hypnotic agent. Proc Bayl Univ Med Cent. 2006 Jan;19(1):54–9.
  7. Eszopiclone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD [Internet]. [cited 2021 Jun 2]. Available from: https://www.webmd.com/drugs/2/drug-92330/eszopiclone-oral/details
  8. Eszopiclone: MedlinePlus Drug Information [Internet]. [cited 2021 Jun 2]. Available from: https://medlineplus.gov/druginfo/meds/a605009.html
  9. Eszopiclone: Side Effects, Dosage, Uses, and More [Internet]. Healthline. 2020 [cited 2021 Jun 2]. Available from: https://www.healthline.com/health/eszopiclone-oral-tablet
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