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In western countries, 6-10% of the adult population is affected by insomnia. Difficulty maintaining sleep, difficulty initiating sleep, frequent awakenings, and sleep deprivation are some of the most common complaints of insomnia. Age-related changes in sleep, depression, medication use, chronic anxiety, and alcoholism are some of the factors contributing to insomnia. (1)
If you wish for a better night's sleep without any disrupted sleep latency, then this article is for you. This article will explain how insomnia can be managed and treated with Eszopiclone and why it is better than other medications.
Eszopiclone is a new generation hypnotic drug and a stereoisomer of Zopiclone. This sedative-hypnotic produces a calming effect by working on special chemicals present in your brain. Eszopiclone comes under different brand names and as a generic drug, helping you fall asleep and stay asleep. (2)
As effective as benzodiazepines, Eszopiclone has been approved by the FDA for treating insomnia by reducing sleep onset latency. Eszopiclone can also be used in combination with different treatment methods like relaxation techniques and behavior modification. (3)
Your brain has some of the very important neurotransmitters called γ- Aminobutyric acid (GABA). GABA receptors are inhibitory receptor, and Eszopiclone works on these receptors to treat insomnia. The mechanism of how Eszopiclone works on these receptors is still not completely understood. But many studies report that Eszopiclone interacts with the complexes of GABA receptors having binding domains located close to benzodiazepine receptors.
Your body tissues, including the brain, quickly absorb the Eszopiclone drug. The liver metabolizes Eszopiclone, which is then converted into its metabolite called N-oxide. The N-oxide metabolite is responsible for inducing and maintaining the sleep effect. (4)
Compared to Zopiclone, Eszopiclone comes with a better safety profile and rapid improvement in chronic insomnia. Let's talk about some research studies reporting the efficacy of Eszopiclone vs Zopiclone.
According to a study, patients were suggested to take 3mg of Eszopiclone and 7.5mg of Zopiclone for one month. The results showed the efficacy of Eszopiclone over Zopiclone for improving sleep efficiency and increasing total sleep time. Both medications showed similar safety profiles. (5)
In another research study, the therapeutic effects of Eszopiclone were investigated. It was reported that you could use Eszopiclone for more than four weeks because Eszopiclone is not limited to short-term use. Moreover, it was suggested that a 3mg dose of Eszopiclone was enough for improved sleep maintenance. (6)
When you start taking Eszopiclone, several health issues must be monitored by you and your doctor. This is important because, in this way, you will be sure that you're safe during the treatment. Clinical monitoring includes:
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