Zopiclone is informally referred to as a "Z-drug." Other Z-drugs, such as zaleplon and zolpidem, were thought to be less addictive than benzodiazepines at first.

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Zopiclone is used to treat insomnia in the short term when sleep initiation or sleep maintenance are prominent symptoms. Long-term use is not advised because tolerance, dependence, and addiction can develop.

Cognitive behavioral therapy has been shown to be more effective than zopiclone in the treatment of insomnia and to have long-term effects on sleep quality for at least a year after treatment.