No products in the cart.
+810 reviews on Trustpilot!
Depression and anxiety are some of the major mental destroyers that affect the lives of approximately 121 million people worldwide, leading to mental health complications like major depressive disorder (MDD) and generalized anxiety disorder (GAD).
Benzodiazepines were considered to be an effective treatment for treating non-panic anxiety. But the withdrawal effects and the risk of dependence after long-term therapy with benzodiazepine therapy has made patients opt for a better treatment option.
Non-benzodiazepines have been proved to be effective for treating anxiety and depression without any adverse side effects. One such antidepressant, non-benzodiazepine, is trazodone hydrochloride as a promising candidate for treating MDD and GAD.
Trazodone has been approved by the FDA to be used as a treatment option for:
Trazodone has sedative actions to improve appetite, energy levels, and mood. It is also a member of the class of drugs called selective serotonin reuptake inhibitors (SSRIs) and serotonin receptor antagonists and reuptake inhibitors (SARIs). If SSRIs prove to be ineffective, trazodone can be a renewed alternative. (1)
Trazodone works by restoring the balance of serotonin receptors of the brain and inducing sedation. Serotonin is a neurotransmitter that impacts your sleep, emotions, and mood. Trazodone increases or restores serotonin to ease anxiety and depression. (2)
Trazodone comes as an off-label medication to treat many other conditions like insomnia, Alzheimer’s disease, and substance abuse.
Being a triazolopyridine derivative, trazodone hydrochloride inhibits serotonin type 2 receptors and serotonin transporter to induce antidepressant effects. It increases the levels of serotonin and increases the serotonin activity in the synaptic cleft by inhibiting the reuptake of serotonin. (3)
Trazodone hydrochloride also blocks alpha-1 adrenergic receptors and histamine to potentiate serotonin activity. Its exact mechanism of action is still unknown, but trazodone is considered to have better tolerance than other SSRIs, which can cause sexual dysfunction and insomnia. (4)
Trazodone is prescribed depending upon the various factors:
At the start, you are recommended to use a low dosage of trazodone HCL, and when it proves to be effective, your doctor increases the dose. It is essential to take the dosage that is prescribed by your doctor only. (6)
The following are some dosages of trazodone HCL for different age groups with anxiety and depression:
For treating generalized anxiety disorder (GAD):
Oral dosage for adults:
Your doctor will recommend divided doses of 150 mg per day PO. Every 3 to 4 days, increase the dose by 50 mg. For inpatients, 600 mg per day PO is prescribed, and for outpatients, a maximum of 400 mg per day PO is prescribed.
For treating depression:
Oral Dose:
Trazodone HCL is usually not recommended as a first-line treatment for this age group. However, divided doses of 1.5-2 mg/kg/day are recommended.
Trazodone HCL is usually not recommended as a first-line treatment for this age group. However, divided doses of 1.5-2 mg/kg/day are recommended.
Your doctor will recommend divided doses of 150 mg per day PO. Every 3 to 4 days, increase the dose by 50 mg. For inpatients, 600 mg per day PO is prescribed, and for outpatients, a maximum of 400 mg per day PO is prescribed.
