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Find A Relief From Your Pain And Injury With The Best Muscle Relaxant: Carisoprodol

June 8, 2021    Dave

If you have low back pain or pain due to injury, you must have been tired of visiting your primary care physicians. Symptoms of skeletal muscle injuries and pain include tingling or burning sensation, weakness, sharp pain, and dull aches. There are several treatment options ranging from pharmacologic measures to non-pharmacologic interventions, but these treatments lack evidence enough to claim their efficacy.

Usually, physical therapy is the most convenient and reliable treatment option for treating muscle pain. Another most efficient treatment option used with physical therapy is Carisoprodol, which comes under different brand names and generic medication. Read on to find more about Carisoprodol.

Carisoprodol: An FDA-Approved Drug

Carisoprodol is an FDA-approved muscle relaxant that relieves you from any discomfort or pain resulting from musculoskeletal conditions, sprains, strains, and injuries. It is used in combination with physical therapy to relax your muscles. In 1959, the United States approved the use of Carisoprodol as a generic medication. The use of Carisoprodol has only been approved for two to three weeks. (1)

Carisoprodol is not recommended to use as a treatment option for spasticity. Carisoprodol is associated with a very low risk of dependence and a low potential for abuse. It makes your muscles relax by directly acting on your central nervous system. If you have painful muscle spasms, you can take Carisoprodol because it owns sedative and anxiolytic effects in its metabolite, meprobamate. (2)

Carisoprodol is only effective for short-term treatment because there’s no evidence available that can claim the efficacy of Carisoprodol for the long term.

How Does Carisoprodol Help in Managing Pain

The exact mechanism of how Carisoprodol relaxes your muscles and relieves you from discomfort and pain is not fully understood. Carisoprodol does not directly relax your skeletal muscles. According to various studies conducted on animal models, it has been reported that a change in the interneuronal activity of the descending reticular formation and spinal cord is associated with Carisoprodol. (3)

The therapeutic effects and abuse potential of Carisoprodol are attributed to its primary metabolite meprobamate that modulates GABA (A) receptor subunits and alters GABA (A) activity. Meprobamate has both sedative and benzodiazepine-related anxiolytic properties. (4, 5)

Like other benzodiazepines, the liver metabolizes Carisoprodol with the help of the CYP2C19 isozyme of the cytochrome P450 oxidase. After its absorption, kidneys excrete Carisoprodol out of the body. With a quick onset of action, 250mg or 350 mg of Carisoprodol starts relaxing your muscles within 1.5 to 1.7 hours.

How to Take Carisoprodol?

Carisoprodol is taken by mouth in the form of a 250 mg or 350 mg tablet. It is taken at bedtime for up to three weeks. Your doctor will prescribe the drug form, how often you should take it, and the dosage depending on:

  • How severe your condition is.
  • Any other existing medical condition
  • Your age
  • How your body reacts to the first dose
  • The condition being treated (6)

Dosage for Different Age Groups:

For seniors of 65 years old:

The medicine should not be used for older adults because the effects of Carisoprodol in adults of 65 years old have not been studied yet.

For Adults (From 17-60 years old):

Carisoprodol should be taken three times a day and before going to bed in 250-350 mg of dose. It means you have to take a total of 1400 mg/day.

For Children (0-16 years):

The effects of this medication have not been confirmed or studied in children yet. So, it is important to not prescribe this medicine to children. (7)

Before Taking This Medication:

Here are some of the precautions you should take before starting to use this medicine:

  • Tell your doctor if you’re pregnant because Carisoprodol can harm your unborn baby (However, the effects of Carisoprodol on unborn baby have not been studied).
  • Speak with your doctor if you’re allergic to Carisoprodol or its metabolite meprobamate. You can also ask for a list of Carisoprodol ingredients from your pharmacist if you suspect that you’re allergic to Carisoprodol’s ingredients.
  • Carisoprodol can make you dizzy or drowsy. So, do not take this medicine before driving or operating machinery.
  • If you have had seizures, liver or kidney disease, you should tell your doctor.
  • If you’re an older adult aged over 65 years, talk to your doctor about the benefits and after-effects of Carisoprodol. (8,9)

 

References:

  1. Toth PP, Urtis J. Commonly used muscle relaxant therapies for acute low back pain: a review of Carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. Clin Ther. 2004 Sep;26(9):1355–67.
  2. Conermann T, Christian D. Carisoprodol. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 [cited 2021 May 30]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK553077/
  3. Carisoprodol [Internet]. [cited 2021 May 30]. Available from: https://go.drugbank.com/drugs/DB00395
  4. Carisoprodol: Abuse Potential and Withdrawal Syndrome: Ingenta Connect [Internet]. [cited 2021 May 30]. Available from: https://www.ingentaconnect.com/content/ben/cdar/2010/00000003/00000001/art00004
  5. Gonzalez LA, Gatch MB, Forster MJ, Dillon GH. Abuse Potential of Soma®: the GABAA Receptor as a Target. Mol Cell Pharmacol. 2009 Jan 1;1(4):180–6.
  6. Carisoprodol | Side Effects, Dosage, Uses and More [Internet]. Healthline. 2017 [cited 2021 May 30]. Available from: https://www.healthline.com/health/carisoprodol-oral-tablet
  7. Soma (Carisoprodol): Uses, Dosage, Side Effects, Interactions, Warning [Internet]. RxList. [cited 2021 May 30]. Available from: https://www.rxlist.com/soma-drug.htm
  8. Carisoprodol: MedlinePlus Drug Information [Internet]. [cited 2021 May 30]. Available from: https://medlineplus.gov/druginfo/meds/a682578.html
  9. Soma: Uses, Dosage, Side Effects & Warnings [Internet]. Drugs.com. [cited 2021 May 30]. Available from: https://www.drugs.com/soma.html

 

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