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Why should you buy modafinil? If you have suffered from excessive daytime sleepiness (EDS), it might be a cause of obstructive sleep apnea (OSA), myotonic dystrophy, shift work disorder, and narcolepsy. Even if you sleep adequately at night, you feel increased fatigue during the daytime. This is causing impaired physical performance and decreased quality of life. If you’re consuming drugs like neuroleptics, antihistamines, or sedatives, you might also suffer from EDS.
This article explains the effectiveness of modafinil for treating daytime sleepiness and its mechanism of action.
Modafinil is a stimulant and wakefulness-promoting agent approved by the US Food and Drug Administration (FDA). If you're a patient with obstructive sleep apnea (OSA), modafinil is prescribed along with positive airway pressure treatment. Your brain contains several chemicals that control sleep and wakefulness. Modafinil changes the amount of these chemicals to prevent EDS. It has also been used in the treatment of some neurodegenerative illnesses as a eugeroic medication. (1)
Unlike other stimulants like amphetamines, modafinil possesses minimal side effects (dependence or hyperarousal) and is considered safe. It comes under different brand names like Provigil® and is quite affordable. (2)
The orexins are sleep-suppressing peptides and wakefulness-promoting peptides, the dysfunction of which causes narcolepsy. It activates the neurons of orexins with the symptoms of euphoria and psychoactivation. If you’re a patient of hypersomnia, this medicine can be really helpful with no complaints of fatigue and lack of energy. (3)
The way modafinil acts in your brain is still unclear. However, various studies have shown that modafinil has a binding affinity for different receptors at different locations. These receptors or neurotransmitters include angiotensin, glycine, dopamine, neurotensin, GABA, and serotonin. (4)
Various in vitro studies have reported that modafinil increases extracellular dopamine by the interaction with the dopamine reuptake pump, thereby inhibiting the dopamine reuptake. Modafinil has also been proved to inhibit GABA and activate glutamatergic circuits. It also stimulates different receptors because of its alpha 1B-adrenergic agonist effects. (5)
Your body is prepared for action when norepinephrine (a neurotransmitter) is activated. Its reuptake is inhibited by modafinil and increases its concentration because norepinephrine is associated with alertness and wakefulness. (6)
Here are some of the incredible benefits of modafinil based on scientific research:
You can take modafinil to treat OSA or narcolepsy with or without food. Modafinil, as approved by the FDA, usually comes in the form of capsules.
For work shift sleep disorder, it is recommended to take it 1 hour before starting your work shift.
The recommended dose of modafinil is 100-200mg taken every morning to promote wakefulness. If you feel well-rested with modafinil, you should continue its use. It is important to note that modafinil is not a cure for your sleep disorder; it only decreases your excessive sleepiness. (11)
A sudden stop to modafinil consumption may cause withdrawal symptoms like shakiness, sweating, dizziness, chills, and confusion. Talk to your doctor If you experience these symptoms.
Modafinil has minimal side effects like anxiety, nausea, fever, restlessness, dizziness, diarrhea, and headaches. Although very few people experience these side effects, awareness of side effects is good. (12)
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